Choose the correct statement about topical NSAID preparations

A) They produce high drug levels in the blood by avoiding hepatic first pass metabolism B) They produce high drug levels in the subjacent muscle and joint tissues upto a depth/distance of 10 cm from the site of application C) They elicit symptomatic relief in soft tissue rheumatism mainly by a strong placebo effect D) Interindividual variability in clinical response to these preparations is minimal