Enzymes - Mock Test 37

Question 361

In Hurler’s syndrome, urine shows the presence of?

A) Keratan sulphate I B) Chondroitin sulphate C) Dermatan sulphate and heparan sulphate D) Keratan sulphate II

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Question 362

The major source of extracellular cholesterol for human tissue is?

A) Very low density lipoprotein B) High density lipoprotein C) Low density lipoprotein D) Albumin

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Question 363

Hypocholesterolemia is found in?

A) Thyrotoxicosis B) Diabetes mellitus C) Obstructive jaundice D) Nephrotic syndrome

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Question 364

The principal rate limiting step in the biosynthesis of bile acids is at the?

A) 7-Hydroxylase reaction B) 12 α-Hydroxylase reaction C) Conjugation reaction D) Deconjugation reaction

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Question 365

The principal sterol excreted in feces is?

A) Coprostanol B) Zymosterol C) Lanosterol D) Desmosterol

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Question 366

The activity of HMG-CoA reductase is inhibited by?

A) A fungal inhibitor mevastatin B) Probucol C) Nicotinic acid D) Clofibrate

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Question 367

Cholesterol by a feed back mechanism inhibits the activity of?

A) HMG-CoA synthetase B) HMG-CoA reductase C) Thilase D) Mevalonate kinase

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Question 368

In the biosynthesis of cholesterol, the rate limiting enzyme is?

A) Mevalonate kinase B) HMG-CoA synthetase C) HMG-CoA reductase D) Cis-prenyl transferase

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Question 369

The cyclisation of squalene in mammals results in the direct formation of the sterol?

A) Cholesterol B) Lanosterol C) Sistosterol D) Zymostero

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Question 370

In the biosynthesis of cholesterol, the step which controls the rate and locus of metabolic regulation is?

A) Geranyl pyrophosphate farnesyl pyrophosphate B) Squalene → lanosterol C) HMG CoA → mevalonate D) Lanosterol → 1, 4-desmethyl lanosterol

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