Mineral Metabolism - Mock Test 29

Question 281

Many xenobiotics?

A) Increase hepatic ALA synthase B) Decrease hepatic ALA sythase C) Increase hepatic ALA dehydrase D) Decrease hepatic ALA dehydrase

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Question 282

The synthesis of heme from protophyrin III is catalysed by the enzyme?

A) ALA synthase B) Ferroreductase C) Ferrooxidase D) Ferrochelatase

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Question 283

Conversion of uroporphyrinogen III to coprophyrinogen III is catalysed by the enzyme?

A) Uroporphyrinogen decarboxylase B) Coproporphyrinogen oxidase C) Protoporphyrinogen oxidase D) Ferrochelatase

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Question 284

Conversion of the linear tetrapyrrole hydroxymethylbilane to uroporphyrinogen III?

A) Occurs spontaneously B) Catalysed by uroporphyrinogen I synthase C) Catalysed by uroporphyrinogen III cosynthase D) Catalysed by combined action of uroporphyrinogen I synthase and uroporphyrinogen III cosynthase

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Question 285

A cofactor required for the activity of the enzyme ALA dehydratase is?

A) Cu B) Mn C) Mg D) Fe

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Question 286

In mammalian liver the rate controlling enzyme in porphyrin biosynthesis is?

A) ALA synthase B) ALA hydratase C) Uroporphyrinogen I synthase D) Uroporphyrinogen III cosynthase

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Question 287

During synthesis of porphyrins, synthesis of δ-amino levulinic acid occurs in?

A) Mitochondria B) Cytosol C) Both in mitochondria and cytosol D) Ribosomes

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Question 288

Porphyrin synthesis is inhibited in?

A) Mercury poisoning B) Lead poisoning C) Manganese poisoning D) Barium poisoning

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Question 289

Heme is synthesized from?

A) Succinyl-CoA and glycine B) Active acetate and glycine C) Active succinate and alanine D) Active acetate and alanine

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Question 290

Porphyrins are synthesized in?

A) Cytosol B) Mitochondria C) Cytosol and mitochondria D) Rough endoplasmic reticulum

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