Nucleic Acids - Mock Test 39

Question 381

Increased urinary excretion of orotic acid can occur in deficiency of?

A) Orotate phosphoribosyl transferase B) OMP decarboxylase C) Mitochondrial ornithine transcarbamoylase D) Any of the above

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Question 382

Complete absence of hypoxanthine guanine phospharibosyl transferase causes?

A) Primary gout B) Immunodeficiency C) Uric acid stones D) Lesh-Nyhan syndrome

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Question 383

Inherited deficiency of adenosine deaminase causes?

A) Hyperuricaemia and gout B) Mental retardation C) Immunodeficiency D) Dwarfism

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Question 384

All of the following occur in orotic aciduria except?

A) Increased synthesis of pyrimidine nucleotides B) Increased excretion of orotic acid in urine C) Decreased synthesis of cytidine triphosphate D) Retardation of growth

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Question 385

Orotic aciduria can be controlled by?

A) Oral administration of orotic acid B) Decreasing the dietary intake of orotic acid C) Decreasing the dietary intake of pyrimidines D) Oral administration of uridine

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Question 386

All of the following statements about allopurinol are true except?

A) It is a structural analogue of uric acid B) It can prevent uric acid stones in the kidneys C) It increases the urinary excretion of xanthine and hypoxanthine D) It is a competitive inhibitor of xanthine oxidase

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Question 387

All of the following statements about primary gout are true except?

A) Uric acid stones may be formed in kidneys B) Arthritis of small joints occurs commonly C) Urinary excretion of uric acid is decreased D) It occurs predominantly in males

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Question 388

All of the following statements about uric acid are true except?

A) It can be formed from allantoin B) Formation of uric acid stones in kidneys can be decreased by alkalinisation of urine C) Uric acid begins to dissociate at pH above 5.8 D) It is present in plasma mainly as monosodium urate

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Question 389

In inherited deficiency of hypoxanthine guanine phosphoribosyl transferase?

A) De novo synthesis of purine nucleotides is decreased B) Salvage of purines is decreased C) Salvage of purines is increased D) Synthesis of uric acid is decreased

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Question 390

All of the following statements about uric acid are true except?

A) It is a catabolite of purines B) It is excreted by the kidneys C) It is undissociated at pH above 5.8 D) It is less soluble than sodium urate

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