Pharmacology - Mock Test 10

Question 91

The present status of oral hypoglycaemics in diabetes mellitus is

A) They are the first choice drug in all cases B) They should be prescribed only if the patient refuses insulin injections C) They are used only in type I diabetes mellitus D) They are used first in most uncomplicated mild to moderate type 2 diabetics

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Question 92

The thiazolidinediones are mainly used as

A) Sole drug in type 1 diabetes mellitus B) Sole drug in type 2 diabetes mellitus C) Addon drug to a sulfonylurea and/or a biguanide in type 2 diabetes mellitus D) Addon drug to insulin in type 1 diabetes mellitus

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Question 93

Choose the correct statement(s) about pioglitazone

A) It acts as an agonist on nuclear paroxisome proliferator receptor γ B) It enhances transcription of insulin responsive genes C) It lowers blood sugar in type 2 diabetes mellitus without causing hyperinsulinemia D) All of the above

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Question 94

Metformin acts by

A) Releasing insulin from pancreas B) Suppressing gluconeogenesis and glucose output from liver C) Up regulating insulin receptors D) Inhibiting degradation of insulin

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Question 95

Which of the following is <u>not</u> a sulfonylurea but acts by analogous mechanism to bring about quick and brief insulin release that is useful for normalizing meal time glycaemic excursions in type 2 diabetes mellitus

A) Glimepiride B) Miglitol C) Repaglinide D) Rosiglitazone

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Question 96

Choose the correct statement about nateglinide

A) It is a long acting oral hypoglycaemic drug B) Taken just before a meal, it limits postprandial hyperglycaemia in type 2 diabetes mellitus C) It lowers blood glucose in both type 1 and type 2 diabetes mellitus D) It acts by opening K⁺ channels in myocytes and adipocytes

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Question 97

The 1st phase of insulin release from pancreatic β cells is augmented by

A) Glibenclamide B) Metformin C) Nateglinide D) Both 'A' and 'C'

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Question 98

Metformin causes little lowering of blood sugar level in

A) Nondiabetics B) Obese diabetics C) Type 2 diabetics D) Diabetics not responding to sulfonylureas

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Question 99

Chlorpropamide is <u>not</u> a preferred sulfonylurea because

A) Hypoglycaemic reaction is more common with it B) Incidence of alcohol intolerance reaction is higher with it C) It can produce cholestatic jaundice D) All of the above

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Question 100

The hypoglycaemic action of sulfonylureas is likely to be attenuated by the concurrent use of

A) Hydrochlorothiazide B) Propranolol C) Theophylline D) Aspirin

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