Pharmacology - Mock Test 11

Question 101

Which of the following drugs can precipitate hypoglycaemia if given to a diabetic controlled with a sulfonylurea drug

A) Phenobarbitone B) Chloramphenicol C) Rifampicin D) Oral contraceptive

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Question 102

Sulfonylurea hypoglycaemics act by

A) Reducing intestinal absorption of glucose B) Increasing insulin secretion from pancreas C) Reversing down-regulation of insulin receptors D) Both ‘B’ and ‘C’ are correct

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Question 103

Sulfonylureas do <u>not</u> lower blood sugar level in

A) Nondiabetics B) Type 1 diabetics C) Type 2 diabetics D) Obese diabetics

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Question 104

Metformin is preferred over phenformin because

A) It is more potent B) It is less liable to cause lactic acidosis C) It does not interfere with vitamin B12 absorption D) It is not contraindicated in patients with kidney disease

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Question 105

The second generation sulfonylurea hypoglycaemics differ from the first generation ones in that they

A) Are more potent B) Are longer acting C) Do not lower blood sugar in nondiabetic subjects D) Are less prone to cause hypoglycaemic reaction

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Question 106

Which of the following is not a specific indication for the more expensive monocomponent/human insulins

A) Insulin resistance B) Pregnant diabetic C) Sulfonylurea maintained diabetic posted for surgery D) Type 1 diabetes mellitus

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Question 107

Compared to pork/beef insulins, the human insulins

A) Are more potent B) Have a faster kinetics of absorption and elimination C) Have longer biological action half life D) Penetrate blood-brain barrier more efficiently

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Question 108

Human insulins are obtained by the following sources/methods <u>except</u>

A) Cadaver pancreas B) Proinsulin recombinant bacterial C) Precursor yeast recombinant D) Enzyme modification of pork insulin

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Question 109

Insulin resistance can be minimized by the use of

A) Corticosteroids B) Tolbutamide C) Protamine D) Monocomponent/human insulin

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Question 110

The monocomponent insulin preparations differ from the conventional preparations in the following respects except

A) They are less allergenic B) They cause less hypoglycaemic reactions C) They cause less lipodystrophy D) They are less liable to induce insulin resistance

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