Pharmacology - Mock Test 25

Question 241

The following antiinflammatory analgesic has been cleared for pediatric use

A) Indomethacin B) Ibuprofen C) Ketorolac D) Piroxicam

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Question 242

Choose the correct statement about topical NSAID preparations

A) They produce high drug levels in the blood by avoiding hepatic first pass metabolism B) They produce high drug levels in the subjacent muscle and joint tissues upto a depth/distance of 10 cm from the site of application C) They elicit symptomatic relief in soft tissue rheumatism mainly by a strong placebo effect D) Interindividual variability in clinical response to these preparations is minimal

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Question 243

Choose the correct statement about nefopam

A) It is a nonopioid analgesic which does not inhibit prostaglandin synthesis B) It is an orally active opioid analgesic C) It is an analgesic with potent antiinflammatory activity D) It is a preferential COX-2 inhibitor

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Question 244

For a patient of peptic ulcer, the safest nonopioid analgesic is

A) Celecoxib B) Diclofenac sodium C) Paracetamol D) Ibuprofen

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Question 245

Paracetamol has the following advantage(s) over NSAIDs

A) It is the first choice analgesic for majority of osteoarthritis patients B) It can be given safely to all age groups from infants to elderly C) It is not contraindicated in pregnant or breast feeding women D) All of the above

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Question 246

N-acetyl cysteine is beneficial in acute paracetamol poisoning because

A) It reacts with paracetamol to form a nontoxic complex B) It inhibits generation of the toxic metabolite of paracetamol C) It is a free radical scavenger D) It replenishes hepatic glutathione which in turn binds the toxic metabolite of paracetamol

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Question 247

Select the drug which inhibits cyclooxygenase in the brain but not at peripheral sites of inflammation

A) Nimesulide B) Paracetamol C) Ketorolac D) Mephenamic acid

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Question 248

Choose the correct statement about paracetamol

A) It increases uric acid excretion B) It is the most common drug implicated in causing analgesic nephropathy C) In equianalgesic doses it is safer than aspirin D) It stimulates cellular metabolism

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Question 249

The selective COX-2 inhibitors have the following advantage(s) over the nonselective NSAIDs

A) They are less likely to cause gastric ulcers and their complications B) They are likely to be more effective in rheumatoid arthritis C) They are not likely to produce renal complications D) All of the above

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Question 250

Among the following, choose the NSAID with the highest COX-2 selectivity

A) Nimesulide B) Nabumetone C) Rofecoxib D) Celecoxib

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