Pharmacology - Mock Test 26

Question 251

The distinctive feature of nimesulide is

A) It does not inhibit prostaglandin synthesis B) It does not cause gastric irritation C) It is usually well tolerated by aspirin intolerant asthma patients D) It is not bound to plasma proteins

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Question 252

What is true of nimesulide

A) It exerts antiinflammatory action by several mechanisms in addition to cyclooxygenase inhibition B) It is preferred for long-term use in rheumatoid arthritis C) It is contraindicated in aspirin intolerant asthma patients D) All of the above

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Question 253

Which of the following is an efficacious antiinflammatory drug but a relatively weak inhibitor of cyclooxygenase

A) Nimesulide B) Paracetamol C) Ketoprofen D) Indomethacin

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Question 254

The following nonsteroidal antiinflammatory drug is a preferential cyclooxygenase-2 ( COX-2 ) inhibitor

A) Tenoxicam B) Meloxicam C) Diclofenac D) Diclonoxicam

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Question 255

Which analgesic-antiinflammatory drug is more appropriate in musculo-skeletal disorder where pain is more prominent than inflammation

A) Ibuprofen B) Piroxicam C) Indomethacin D) Nimesulide

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Question 256

The constellation of adverse effects associated with nonsteroidal antiinflammatory drugs include the following <u>except</u>

A) Sedation B) Gastric irritation C) Fluid retention D) Rashes

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Question 257

Choose the correct statement about nonsteroidal antiinflammatory drugs (NSAIDs)

A) NSAIDs attenuate hypoglycaemic action of sulfonylureas B) NSAIDs potentiate antihypertensive action of ACE inhibitors C) Serum lithium levels are lowered by concurrent administration of NSAIDs D) Combined therapy with prednisolone and NSAIDs carries higher risk of gastric bleeding

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Question 258

The patient taking the following non-steroidal antiinflammatory drug should be cautioned not to drive motor vehicle

A) Celecoxib B) Indomethacin C) Naproxen D) Diclofenac sodium

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Question 259

Which of the following analgesics itself frequently causes headache as a side effect

A) Indomethacin B) Mephenamic acid C) Piroxicam D) Metamizol

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Question 260

The NSAIDs aggravate the following diseases except

A) Hypertension B) Congestive heart failure C) Peptic ulcer D) Chronic gout

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