Pharmacology - Mock Test 27

Question 261

Phenylbutazone should be used only in patients not responding to other nonsteroidal antiinflammatory drugs (NSAIDs) because

A) It has lower antiinflammatory efficacy than other NSAIDs B) It has potential to cause agranulocytosis C) It has weak analgesic action D) It alters the protein binding and metabolism of many drugs

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Question 262

Selective inhibition of thromboxane A2 synthesis by low dose aspirin therapy might retard the progression of

A) Pregnancy induced hypertension B) Steroid induced hypertension C) Renal hypertension D) Malignant hypertension

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Question 263

Choose the action for which the dose of aspirin required is the lowest

A) Analgesic B) Antipyretic C) Antiinflammatory D) Antiplatelet aggregatory

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Question 264

Choose the correct statement about aspirin

A) In an afebrile patient acute overdose of aspirin produces hypothermia B) Aspirin suppresses flushing attending large dose of nicotinic acid C) Aspirin therapy prevents granulomatous lesions and cardiac complications of acute rheumatic fever D) Long term aspirin therapy increases the risk of developing colon cancer

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Question 265

Concurrent administration of aspirin interacts unfavourably with the following drugs except

A) Furosemide B) Spironolactone C) Codeine D) Methotrexate

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Question 266

Aspirin is contraindicated in pregnant women near term because

A) Labour may be delayed and prolonged B) Blood loss during delivery may be more C) Foetus may suffer premature closure of ductus arteriosus D) All of the above risks

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Question 267

Aspirin is contraindicated in children suffering from influenza or similar viral infection because of increased risk of

A) Gastric bleeding B) Thrombocytopenia C) Fancony syndrome D) Reye’s syndrome

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Question 268

Generally the earliest manifestation of salicylism is

A) Visual disturbance B) Excitement C) Hyperventillation D) Tinnitus

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Question 269

In the treatment of chronic inflammatory diseases, the most important limitation of aspirin is

A) Acid-base and electrolyte disturbances B) Hypersensitivity and idiosyncratic reactions C) Gastric mucosal damage D) Salicylism

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Question 270

The plasma half life of aspirin (along with salicylic acid released from it)

A) Remains constant irrespective of dose B) Is longer for antiinflammatory doses compared to that for analgesic dose C) Is shorter for antiinflammatory doses compared to that for analgesic dose D) Can be shortened by acidifying urine

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