Pharmacology - Mock Test 28

Question 271

Antiinflammatory dose of aspirin given to diabetics is prone to cause

A) Hyperglycaemia B) Hypoglycaemia C) Ketoacidosis D) Alkalosis

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Question 272

The isoenzyme cyclooxygenase-2 ( COX-2 ) is expressed constitutively at the following site

A) Gastric mucosa B) Neutrophils C) Blood platelets D) Juxtaglomerular apparatus

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Question 273

Aspirin reduces fever by

A) Decreasing heat production in the body B) Enhancing cutaneous blood flow C) Inducing sweating D) Both ‘B’ and ‘C’ are correct

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Question 274

Which of the following is seen at low ( analgesic ) doses of aspirin

A) Respiratory stimulation B) Increased occult blood loss in stools C) Increased cardiac output D) Hyperglycaemia

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Question 275

Metabolic effects that generally attend antiinflammatory doses of aspirin include the following except

A) Increased CO2 production B) Hepatic glycogen depletion C) Metabolic acidosis D) Compensated respiratory alkalosis

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Question 276

Inhibition of prostaglandin synthesis does not underlie the following action of aspirin

A) Analgesia B) Closure of patent ductus arteriosus C) Hyperventilation D) Bleeding tendency

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Question 277

Selective COX-2 inhibitors differ from nonselective COX-1/COX-2 inhibitors in that they

A) Are antiinflammatory but not analgesic B) Donot bring down fever C) Have no renal effects D) Do not inhibit platelet aggregation

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Question 278

Inhibitors of prostaglandin synthesis share the following features <u>except</u>

A) Prolongation of bleeding time B) Prolongation of prothrombin time C) Prolongation of labour D) Gastric mucosal damage

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Question 279

Select the drug which inhibits cyclooxygenase irreversibly

A) Aspirin B) Mephenamic acid C) Naproxen D) Diclofenac

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Question 280

Aspirin produces analgesia by

A) Preventing sensitization of peripheral pain receptors B) Affecting gating of pain impulses at spinal level C) Raising pain threshold at subcortical level D) Both ‘A’ and ‘C’ are correct

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