Pharmacology - Mock Test 30

Question 291

Aspirin in low doses produces longlasting inhibition of platelet cyclooxygenase (COX) because

A) Platelets contain low quantity of COX B) Platelets cannot synthesize fresh COX molecules C) Platelets bind aspirin with high affinity D) Platelet COX is inducible

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Question 292

Low doses of aspirin prolong bleeding time by selectively inhibiting synthesis of the following mediator in the platelets

A) Thromboxane Aâ‚‚ B) 5-Hydroxytryptamine C) Platelet activating factor D) Prostacyclin

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Question 293

Prostaglandins play pathophysiological role in the following <u>except</u>

A) Patency of ductus arteriosus B) Regulation of renal tubular salt absorption C) Ventricular remodeling after myocardial infarction D) Initiation of labour

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Question 294

The following prostanoid is a potent inducer of platelet aggregation

A) Prostacyclin B) Prostaglandin Eâ‚‚ C) Prostaglandin Dâ‚‚ D) Thromboxane Aâ‚‚

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Question 295

Actions of prostaglandin Eâ‚‚ include the following except

A) Fall in blood pressure B) Bronchoconstriction C) Uterine contraction D) Inhibition of gastric acid secretion

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Question 296

Dysmenorrhoea is often associated with excess production of the following autacoid by the endometrium

A) Bradykinin B) Prostaglandin C) Platelet activating factor D) 5-Hydroxytryptamine

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Question 297

Which of the following is an irreversible inhibitor of cyclooxygenase

A) Aspirin B) Phenylbutazone C) Indomethacin D) Piroxicam

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Question 298

The cyclooxygenase isoenzymes COX-1 and COX-2 differ from each other in that

A) They catalyse different pathways in prostanoid biosynthesis B) COX-1 is inhibited by aspirin but not COX-2 C) COX-2 is inhibited by ibuprofen but not COX-1 D) COX-1 is constitutive while COX-2 is largely inducible

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Question 299

There are no preformed stores of the following autacoid/autacoids

A) Prostaglandins B) Leukotrienes C) Angiotensin II D) All of the above

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Question 300

The following eicosanoid is generated through the lipoxygenase pathway

A) Prostaglandin Eâ‚‚ B) Thromboxane Aâ‚‚ C) Leukotriene Câ‚„ D) Prostacyclin

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