Pharmacology - Mock Test 31

Question 301

The calcium channel blocker used for prophylaxis of migraine but not for angina pectoris is

A) Verapamil B) Diltiazem C) Flunarizine D) Amlodipine

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Question 302

Prophylactic therapy of migraine

A) Is recommended in all cases B) Benefits upto 70% patients of moderate to severe migraine C) Needs to be continued lifelong without interruption D) Reduces the severity but increases the frequency of migraine attacks

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Question 303

Select the β blocker which does not afford prophylaxis in migraine

A) Propranolol B) Timolol C) Atenolol D) Pindolol

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Question 304

Which of the following drugs is most commonly used for prophylaxis of migraine

A) Ergotamine B) Propranolol C) Methysergide D) Sumatriptan

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Question 305

Choose the correct statement about sumatriptan

A) It activates serotonergic neurones in raphe nuclei B) It tends to suppress both pain and vomiting in migraine C) It does not carry risk of precipitating coronary vasospasm D) It is combined with ergotamine for treatment of severe migraine

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Question 306

The most important risk in the use of sumatriptan for treatment of migraine is

A) Precipitation of seizures B) Precipitation of psychosis C) Development of hypertension D) Coronary vasospasm

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Question 307

Ergotamine relieves migraine by

A) Blocking vascular α adrenergic receptors B) Blocking vascular 5-HT₂ receptors C) Dilating cranial arterio-venous shunt channels D) Constricting cranial vessels and reducing perivascular neurogenic inflammation

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Question 308

The nonsteroidal antiinflammatory drugs are more effective in migraine

A) Without aura B) With aura C) Than ergotamine D) When combined with propranolol

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Question 309

Select the correct statement in relation to drug therapy of migraine

A) Simple analgesics like paracetamol are ineffective in migraine B) Ergot alkaloids are used for prophylaxis as well as treatment of migraine attacks C) Use of ergot alkaloids is restricted to severe or resistant cases D) Ergot alkaloids should be given till 24 hours after an attack has subsided

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Question 310

The ‘amine’ ergot alkaloid differs from ‘amino acid’ ergot alkaloid in that it has

A) High oral bioavailability B) Better CNS penetrability C) Weaker oxytocic action D) Strong anti-5-HT action

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