Pharmacology - Mock Test 32

Question 311

Select the ergot compound which is primarily used for dementia

A) Bromocriptine B) Ergotamine C) Codergocrine D) Methysergide

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Question 312

Choose the ergot alkaloid that is well absorbed orally, has weak vascular but prominent uterine stimulant action

A) Ergometrine B) Ergotamine C) Dihydroergotamine D) Dihydroergotoxine

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Question 313

Dihydroergotamine (DHE) differs from ergotamine in the following respect

A) It is a more potent oxytocic B) It has antiemetic property C) It has high oral bioavailability D) It is a more potent α adrenergic blocker and less potent vasoconstrictor

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Question 314

Methysergide has lost popularity as a prophylactic drug for migraine because of its

A) Poor efficacy B) Potential to cause visceral fibrosis C) Oxytocic action D) Potential to aggravate ischaemic heart disease

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Question 315

The following is a selective 5-HTâ‚„ agonist

A) Buspirone B) Sumatriptan C) Cisapride D) Clozapine

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Question 316

The most important receptor involved in cytotoxic drug induced vomiting is

A) Histamine H₁ receptor B) Serotonin 5-HT₃ receptor C) Dopamine D₂ receptor D) Opioid μ receptor

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Question 317

5-HT appears to play a role in the following <u>except</u>

A) Regulation of normal BP B) Regulation of intestinal peristalsis C) Haemostasis D) Causation of migraine

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Question 318

The smooth muscle stimulating action of 5-HT is most marked in the

A) Bronchi B) Intestines C) Ureter D) Biliary tract

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Question 319

Actions of 5-HTâ‚‚ receptor activation are primarily mediated by

A) Increased membrane permeability to Na+ ions B) Increased formation of cAMP C) Activation of guanylyl cyclase D) Generation of inositol trisphosphate and diacyl glycerols

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Question 320

Tachyphylaxis to many actions on repeated injection is a feature of the following autacoid

A) Histamine B) 5-Hydroxytryptamine C) Bradykinin D) Prostaglandin Eâ‚‚

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