Pharmacology - Mock Test 33

Question 321

The following 5-HT receptor is not a G protein coupled receptor

A) 5-HT₁ B) 5-HT₂ C) 5-HT₃ D) 5-HT₄

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Question 322

The typical response to intravenous injection of 5-HT in an anaesthetised animal is

A) Rise in BP B) Fall in BP C) Rise followed by brief fall in BP D) Transient fall, followed by brief rise, followed by prolonged fall in BP

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Question 323

The following action of 5-Hydroxy tryptamine is mediated by the 5-HT₃ receptor

A) Vasoconstriction B) Bradycardia C) EDRF release D) Platelet aggregation

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Question 324

The following biogenic amine is not actively taken up into its storage site by an active amine pump

A) Histamine B) 5-Hydroxy tryptamine C) Dopamine D) Noradrenaline

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Question 325

Benefit afforded by certain H₁ antihistaminics in the following condition is not based on antagonism of histamine

A) Dermographism B) Insect bite C) Common cold D) Seasonal hay fever

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Question 326

H₁ antihistaminics are beneficial in

A) All types of allergic disorders B) Certain type I allergic reactions only C) Certain type IV allergic reactions only D) Bronchial asthma

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Question 327

Select the H₁ antihistaminic which is used topically in the nose for allergic rhinitis

A) Loratadine B) Cetirizine C) Fexofenadine D) Azelastine

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Question 328

Fexofenadine differs from terfenadine in that

A) It undergoes high first pass metabolism in liver B) It is a prodrug C) It does not block cardiac delayed rectifier K⁺ channels D) It has high affinity for central H₁ receptors

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Question 329

Erythromycin should not be given to a patient being treated with terfenadine because

A) Erythromycin induces the metabolism of terfenadine B) Dangerous ventricular arrhythmias can occur C) Terfenadine inhibitis metabolism of erythromycin D) Terfenadine antagonizes the antimicrobial action of erythromycin

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Question 330

Select the antihistaminic which modulates calcium channels and has prominant labyrinthine suppressant property

A) Cyproheptadine B) Cinnarizine C) Clemastine D) Cetirizine

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