Pharmacology - Mock Test 34

Question 331

Select the antihistaminic which blocks cardiac K⁺ channels when given in high doses or along with drugs that inhibit CYP3A4 isoenzyme

A) Chlorpheniramine B) Promethazine C) Astemizole D) Loratadine

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Question 332

The following second generation anti-histaminic is not likely to produce ventricular arrhythmias when administered along with ketoconazole

A) Mizolastine B) Ebastine C) Terfenadine D) Astemizole

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Question 333

The second generation H₁ antihistaminics have the following advantages <u>except</u>

A) Lack of anticholinergic side effects B) Lack of alcohol potentiating potential C) Recipient can drive motor vehicles D) Good antipruritic action

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Question 334

The following is not a feature of second generation antihistaminics

A) Nonimpairment of psychomotor performance B) High antimotion sickness activity C) Absence of anticholinergic/anti 5-HT actions D) Additional mechanisms of antiallergicaction

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Question 335

While prescribing a first generation H₁ antihistaminic the patient should be advised to avoid

A) Driving motor vehicles B) Consuming processed cheese C) Strenuous physical exertion D) All of the above

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Question 336

The capacity of an antihistaminic to produce sedation depends on the following except

A) Relative affinity for central versus peripheral H₁ receptors B) Ability to penetrate blood-brain barrier C) Individual susceptibility D) Ratio of H₁:H₂ blockade produced by the drug

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Question 337

The conventional H₁ antihistaminics possess the following additional properties <u>except</u>

A) Local anaesthetic B) Vasopressor C) Antiarrhythmic D) Catecholamine potentiating

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Question 338

The following H₁ antihistaminic has additional anti 5-HT, anticholinergic, sedative and appetite stimulating properties

A) Promethazine B) Terfenadine C) Cyproheptadine D) Hydroxyzine

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Question 339

High anticholinergic property is present in the following antihistaminic

A) Diphenhydramine B) Astemizole C) Cetirizine D) Terfenadine

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Question 340

The drug that can directly release histamine from mast cells without involving antigen-antibody reaction is

A) Aspirin B) Procaine C) Morphine D) Sulfadiazine

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