Pharmacology - Mock Test 4

Question 31

Select the correct statement about tibolone

A) It is an antiestrogen used for palliative treatment of carcinoma breast B) It is an estrogenic + progestational steroid used for hormone replacement therapy in postmenopausal women C) It is an antiandrogen used for male pattern baldness D) It is a nonsteroidal estrogen used topically for senile vaginitis

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Question 32

Select the compound which used for hormone replacement therapy in postmenopausal women serves the purpose of both estrogen and progestin with weak androgenic activity

A) Tibolone B) Mestranol C) Desogestrel D) Gestodene

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Question 33

The daily dose of estrogen for hormone replacement therapy in postmenopausal women is

A) Same as for contraception B) Higher than that for contraception C) Lower than that for contraception D) Variable depending on the age of the woman

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Question 34

The estrogen commonly used for hormone replacement therapy in menopausal women is

A) Ethinylestradiol B) Estradiol benzoate C) Diethylstilbestrol D) Conjugated estrogens

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Question 35

Addition of a progestin for 10-12 days each month to estrogen replacement therapy in menopausal women is recommended because the progestin

A) Blocks the increased risk of myocardial infarction due to estrogen B) Blocks the increased risk of endometrial carcinoma due to estrogen C) Reverses vulval atrophy occurring in postmenopausal women D) Enhances the metabolic benefits of estrogen treatment

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Question 36

Estrogen therapy can worsen the following associated conditions except

A) Migraine B) Cholelithiasis C) Acne vulgaris D) Endometriosis

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Question 37

Which of the following statements most closely reflects the current status of estrogens in postmenopausal women

A) Estrogens should be prescribed routinely to all menopausal women B) Estrogens should be prescribed when menopausal symptoms are severe C) Estrogens should be prescribed only when there is radiological evidence of osteoporosis D) Estrogens should be prescribed along with a progestin after considering risk:benefit ratio in individual patients

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Question 38

In which of the following conditions estrogen is not the primary drug but is added to progestin as adjuvant

A) Dysfunctional uterine bleeding B) Menopausal syndrome C) Osteoporosis D) Atrophic vaginitis

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Question 39

Transdermal estradiol differs from oral estrogen therapy in that it

A) Causes less induction of hepatic synthesis of clotting factors B) Does not inhibit FSH secretion C) Does not affect vaginal cytology D) All of the above are correct

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Question 40

Metabolic actions of estrogens tend to cause the following <u>except</u>

A) Anabolism B) Impaired glucose tolerance C) Rise in plasma LDL-cholesterol D) Salt and water retention

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