Pharmacology - Mock Test 51

Question 501

The following is a competitive antagonist of GABA but a noncompetitive antagonist of diazepam

A) Picrotoxin B) Muscimol C) Flumazenil D) Bicuculline

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Question 502

The following is not a feature of competitive antagonists

A) Chemical resemblance with the agonist B) Parallel rightward shift of the agonist log doseresponse curve C) Suppression of maximal agonist response D) Apparent reduction in agonist affinity for the receptor

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Question 503

A drug which does not produce any action by itself but decreases the slope of the log dose-response curve and suppresses the maximal response to another drug is a

A) Physiological antagonist B) Competitive antagonist C) Noncompetitive antagonist D) Partial agonist

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Question 504

A drug ‘R’ producing no response by itself causes the log dose-response curve of another drug ‘S’ to shift to the right in a parallel manner without decreasing the maximal response: Drug ‘R’ is a

A) Partial agonist B) Inverse agonist C) Competitive antagonist D) Noncompetitive antagonist

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Question 505

The antidotal action of sodium nitrite in cyanide poisoning is based on

A) Physical antagonism B) Chemical antagonism C) Physiological antagonism D) Noncompetitive antagonism

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Question 506

The antagonism between adrenaline and histamine is called ‘physiological antagonism’ because

A) Both are physiologically present in the body B) They act on physiological receptors C) Both affect many physiological processes D) They have opposite physiological effects

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Question 507

If the effect of combination of two drugs is equal to the sum of their individual effects, the two drugs are exhibiting

A) Potentiation B) Synergism C) Cross tolerance D) Antagonism

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Question 508

Compared to the drug named within parenthesis, which of the following drugs has a higher potency but lower efficacy

A) Pethidine (morphine) B) Furosemide (hydrochlorothiazide) C) Diazepam (pentobarbitone) D) Enalapril (captopril)

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Question 509

The therapeutic index of a drug is a measure of its

A) Safety B) Potency C) Efficacy D) Dose variability

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Question 510

If the dose-response curves of a drug for producing different actions are widely separated on the dose axis, the drug is

A) Highly potent B) Highly efficacious C) Highly toxic D) Highly selective

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