Pharmacology - Mock Test 53

Question 521

Agonist induced autophosphorylation, internalization and down regulation is a distinctive feature of

A) G-protein coupled receptors B) Intrinsic ion channel containing receptors C) Tyrosine protein kinase receptors D) Receptors regulating gene expression

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Question 522

Select the receptor that is located intracellularly

A) Opioid μ receptor B) Steroid receptor C) Prostaglandin receptor D) Angiotensin receptor

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Question 523

Which of the following is a G protein coupled receptor

A) Muscarinic cholinergic receptor B) Nicotinic cholinergic receptor C) Glucocorticoid receptor D) Insulin receptor

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Question 524

The following receptor type has 7 helical membrane spanning amino acid segments with 3 extracellular and 3 intracellular loops

A) Tyrosine protein kinase receptor B) Gene expression regulating receptor C) Intrinsic ion channel containing receptor D) G protein coupled receptor

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Question 525

Receptors perform the following function/functions

A) Ligand recognition B) Signal transduction C) Both ligand recognition and signal transduction D) Disposal of agonists and antagonists

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Question 526

Agonists affect the receptor molecule in the following manner

A) Alter its amino acid sequence B) Denature the receptor protein C) Alter its folding or alignment of subunits D) Induce covalent bond formation

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Question 527

Receptor agonists possess

A) Affinity but no intrinsic activity B) Intrinsic activity but no affinity C) Affinity and intrinsic activity with a + sign D) Affinity and intrinsic activity with a – sign

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Question 528

A partial agonist can antagonise the effects of a full agonist because it has

A) High affinity but low intrinsic activity B) Low affinity but high intrinsic activity C) No affinity and low intrinsic activity D) High affinity but no intrinsic activity

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Question 529

Study of drug-receptor interaction has now shown that

A) Maximal response occurs only when all receptors are occupied by the drug B) Drugs exert an ‘all or none’ action on a receptor C) Receptor and drugs acting on it have rigid complementary ‘lock and key’ structural features D) Properties of ‘affinity’ and ‘intrinsic activity’ are independently variable

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Question 530

Drugs acting through receptors exhibit the following features except

A) Structural specificity B) High potency C) Competitive antagonism D) Dependence of action on lipophilicity

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