Pharmacology - Mock Test 54

Question 531

What is true in relation to drug receptors

A) All drugs act through specific receptors B) All drug receptors are located on the surface of the target cells C) Agonists induce a conformational change in the receptor D) Partial agonists have low affinity for the receptor

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Question 532

Which of the following drugs acts by inhibiting an enzyme in the body

A) Atropine B) Allopurinol C) Levodopa D) Metoclopramide

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Question 533

Sustained/controlled release oral dosage form is appropriate for the following type of drug

A) An antiarthritic with a plasma half life of 24 hr B) A sleep inducing hypnotic with a plasma half life of 2 hours C) An antihypertensive with a plasma half life of 3 hours D) An analgesic with a plasma half life of 6 hours used for relief of casual headache

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Question 534

Monitoring plasma drug concentration is useful while using

A) Antihypertensive drugs B) Levodopa C) Lithium carbonate D) MAO inhibitors

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Question 535

Monitoring of blood levels of diuretic drugs is not practised because

A) No sensitive methods for measuring blood levels of diuretics are available B) It is easier to measure the effect of these drugs C) Response to diuretics is not related to their blood levels D) Diuretics need activation in the body

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Question 536

The loading dose of a drug is governed by its

A) Renal clearance B) Plasma half life C) Volume of distribution D) Elimination rate constant

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Question 537

When the same dose of a drug is repeated at half life intervals, the steady-state (plateau) plasma drug concentration is reached after

A) 2–3 half lives B) 4–5 half lives C) 6–7 half lives D) 8–10 half lives

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Question 538

If the clearance of a drug remains constant, doubling the dose rate will increase the steady-state plasma drug concentration by a factor of

A) 3 B) 2 C) 1.5 D) 1.3

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Question 539

If a drug has a constant bioavailability and first order elimination, its maintenance dose rate will be directly proportional to its

A) Volume of distribution B) Plasma protein binding C) Lipid solubility D) Total body clearance

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Question 540

If a drug is eliminated by first order kinetics

A) A constant amount of the drug will be eliminated per unit time B) Its clearance value will remain constant C) Its elimination half life will increase with dose D) It will be completely eliminated from the body in 2 × half life period

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