Pharmacology - Mock Test 55

Question 541

Which of the following is <u>not</u> a primary/fundamental, but a derived pharmacokinetic parameter

A) Bioavailability B) Volume of distribution C) Clearance D) Plasma half life

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Question 542

If a drug is excreted in urine at the rate of 10 mg/hr at a steady-state plasma concentration of 5 mg/L, then its renal clearance is

A) 0.5 L/hr B) 2.0 L/hr C) 5.0 L/hr D) 20 L/hr

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Question 543

The plasma half life of penicillin-G is longer in the new born because their

A) Plasma protein level is low B) Drug metabolizing enzymes are immature C) Glomerular filtration rate is low D) Tubular transport mechanisms are not well developed

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Question 544

If a drug undergoes net tubular secretion, its renal clearance will be

A) More than the glomerular filtration rate B) Equal to the glomerular filtration rate C) Less than the glomerular filtration rate D) Equal to the rate of urine formation

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Question 545

Glomerular filtration of a drug is affected by its

A) Lipid solubility B) Plasma protein binding C) Degree of ionization D) Rate of tubular secretion

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Question 546

Drugs which undergo high degree of first-pass metabolism in liver

A) Have low oral bioavailability B) Are excreted primarily in bile C) Are contraindicated in liver disease D) Exhibit zero order kinetics of elimination

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Question 547

Select the drug that undergoes extensive first-pass metabolism in the liver

A) Phenobarbitone B) Propranolol C) Phenylbutazone D) Theophylline

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Question 548

The following drug metabolizing reaction is entirely nonmicrosomal

A) Glucuronide conjugation B) Acetylation C) Oxidation D) Reduction

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Question 549

Microsomal enzyme induction can be a cause of

A) Tolerance B) Physical dependence C) Psychological dependence D) Idiosyncrasy

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Question 550

The most commonly occurring conjugation reaction for drugs and their metabolites is

A) Glucuronidation B) Acetylation C) Methylation D) Glutathione conjugation

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