Pharmacology - Mock Test 57

Question 561

A nonvolatile, highly lipid soluble drug is metabolized at a rate of 15% per hour. On intravenous injection it produces general anaesthesia for 10 min. Which process is responsible for termination of its action

A) Metabolism in liver B) Plasma protein binding C) Excretion by kidney D) Redistribution

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Question 562

Marked redistribution is a feature of

A) Highly lipid soluble drugs B) Poorly lipid soluble drugs C) Depot preparations D) Highly plasma protein bound drugs

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Question 563

The following attribute of a drug tends to reduce its volume of distribution

A) High lipid solubility B) Low ionisation at physiological pH values C) High plasma protein binding D) High tissue binding

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Question 564

If the total amount of a drug present in the body at a given moment is 2.0 g and its plasma concentration is 25 μ g/ml, its volume of distribution is

A) 100 L B) 80 L C) 60 L D) 50 L

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Question 565

The most important factor governing absorption of a drug from intact skin is

A) Molecular weight of the drug B) Site of application C) Lipid solubility of the drug D) Nature of the base used in the formulation

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Question 566

Bioavailability differences among oral formulations of a drug are most likely to occur if the drug

A) Is freely water soluble B) Is completely absorbed C) Is incompletely absorbed D) Undergoes little first-pass metabolism

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Question 567

Bioavailability of drug refers to

A) Percentage of administered dose that reaches systemic circulation in the unchanged form B) Ratio of oral to parenteral dose C) Ratio of orally administered drug to that excreted in the faeces D) Ratio of drug excreted unchanged in urine to that excreted as metabolites

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Question 568

Tricyclic antidepressants can alter the oral absorption of many drugs by

A) Complexing with the other drug in the intestinal lumen B) Altering gut motility C) Altering gut flora D) Damaging gut mucosa

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Question 569

Active transport of a substance across biological membranes has the following characteristics except

A) It is specific B) It is pH dependent C) It is saturable D) It requires metabolic energy

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Question 570

The most important factor which governs diffusion of drugs across capillaries other than those in the brain is

A) Blood flow through the capillary B) Lipid solubility of the drug C) pKa value of the drug D) pH of the medium

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