Pharmacology - Mock Test 59

Question 581

Drug administered through the following route is most likely to be subjected to first-pass metabolism

A) Oral B) Sublingual C) Subcutaneous D) Rectal

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Question 582

An 'orphan drug' is

A) A very cheap drug B) A drug which has no therapeutic use C) A drug needed for treatment or prevention of a rare disease D) A drug which acts on Orphanin receptors

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Question 583

`Essential drugs’ are

A) Life saving drugs B) Drugs that meet the priority health care needs of the population C) Drugs that must be present in the emergency bag of a doctor D) Drugs that are listed in the pharmacopoia of a country

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Question 584

Systemic clearance (CLs) is related with

A) Only the concentration of substances in plasma B) Only the elimination rate constant C) Volume of distribution, half life and elimination rate constant D) Bioavailability and half life

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Question 585

Elimination rate constant is defined by the following parameter

A) Rate of absorption B) Maximal concentration of a substance in plasma C) Highest single dose D) Half life (t ½)

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Question 586

Elimination is expressed as follows

A) Rate of renal tubular reabsorption B) Clearance speed of some volume of blood from substance C) Time required to decrease the amount of drug in plasma by one-half D) Clearance of an organism from a xenobiotic

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Question 587

Half life (t ½) is the time required to

A) Change the amount of a drug in plasma by half during elimination B) Metabolize a half of an introduced drug into the active metabolite C) Absorb a half of an introduced drug D) Bind a half of an introduced drug to plasma proteins

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Question 588

In case of liver disorders accompanied by a decline in microsomal enzyme activity the duration of action of some drugs is

A) Decreased B) Enlarged C) Remained unchanged D) Changed insignificantly

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Question 589

Conjugation of a drug includes the following EXCEPT

A) Glucoronidation B) Sulfate formation C) Hydrolysis D) Methylation

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Question 590

Which of the following processes proceeds in the second phase of biotransformation

A) Acetylation B) Reduction C) Oxidation D) Hydrolysis

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