Pharmacology - Mock Test 60

Question 591

Conjugation is

A) Process of drug reduction by special enzymes B) Process of drug oxidation by special oxidases C) Coupling of a drug with an endogenous substrate D) Solubilization in lipids

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Question 592

Biotransformation of a medicinal substance results in

A) Faster urinary excretion B) Slower urinary excretion C) Easier distribution in organism D) Higher binding to membranes

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Question 593

Metabolic transformation ( phase 1 ) is

A) Acetylation and methylation of substances B) Transformation of substances due to oxidation, reduction or hydrolysis C) Glucuronide formation D) Binding to plasma proteins

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Question 594

Stimulation of liver microsomal enzymes can

A) Require the dose increase of some drugs B) Require the dose decrease of some drugs C) Prolong the duration of the action of a drug D) Intensify the unwanted reaction of a drug

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Question 595

Pick out the right statement

A) Microsomal oxidation always results in inactivation of a compound B) Microsomal oxidation results in a decrease of compound toxicity C) Microsomal oxidation results in an increase of ionization and water solubility of a drug D) Microsomal oxidation results in an increase of lipid solubility of a drug thus its excretion from the organism is facilitated

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Question 596

Tick the drug type for which microsomal oxidation is the most prominent

A) Lipid soluble B) Water soluble C) Low molecular weight D) High molecular weight

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Question 597

Biotransformation of the drugs is to render them

A) Less ionized B) More pharmacologically active C) More lipid soluble D) Less lipid soluble

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Question 598

The term “biotransformation” includes the following

A) Accumulation of substances in a fat tissue B) Binding of substances with plasma proteins C) Accumulation of substances in a tissue D) Process of physicochemical and biochemical alteration of a drug in the body

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Question 599

For the calculation of the volume of distribution ( Vd ) one must take into account

A) Concentration of a substance in plasma B) Concentration of substance in urine C) Therapeutical width of drug action D) A daily dose of drug

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Question 600

What is the reason of complicated penetration of some drugs through brain-blood barrier

A) High lipid solubility of a drug B) Meningitis C) Absence of pores in the brain capillary endothelium D) High endocytosis degree in a brain capillary

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