Pharmacology - Mock Test 8

Question 71

The following form of corticosteroid therapy carries the maximum adverse effect potential

A) Prednisolone 20 mg/day oral for one year B) Prednisolone 60 mg/day oral for 7 days C) Dexamethasone 4 mg intravenous twice daily for 3 days D) Methyl-prednisolone 1000 mg intravenous single dose

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Question 72

The corticosteroid preferred for replacement therapy in Addison’s disease is

A) Aldosterone B) Fludrocortisone C) Hydrocortisone D) Betamethasone

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Question 73

Select the compound that is preferred for high dose intravenous corticosteroid pulse therapy

A) Cortisone B) Hydrocortisone C) Triamcinolone D) Methyl prednisolone

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Question 74

Dexamethasone differs from prednisolone in that it is

A) Longer acting B) More potent C) More selective D) All of the above

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Question 75

Select the corticosteroid with the lowest oral: parenteral activity ratio

A) Prednisolone B) Methyl prednisolone C) Hydrocortisone D) Dexamethasone

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Question 76

The following glucocorticoid has significant mineralocorticoid activity also

A) Hydrocortisone B) Triamcinolone C) Dexamethasone D) Betamethasone

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Question 77

The most important mechanism of antiinflammatory action of glucocorticoids is

A) Inhibition of lysosomal enzymes B) Restriction of recruitment of inflammatory cells at the site of inflammation C) Antagonism of action of interleukins D) Suppression of complement function

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Question 78

The glucocorticoid receptor is located

A) On the outer surface of the cell membrane B) On the inner surface of the cell membrane C) In the cytoplasm D) Inside the nucleus

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Question 79

Corticosteroids exert antiinflammatory action by inhibiting the following enzyme

A) Cyclooxygenase B) Lipoxygenase C) Phospholipase-A D) Phosphodiesterase

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Question 80

Glucocorticoids impair carbohydrate tolerance by

A) Promoting gluconeogenesis in liver B) Depressing glucose uptake into skeletal muscles C) Inhibiting insulin secretion D) Both A and B are correct

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