Pharmacology - Comprehensive Mock Test 23

Question 221 Hard

If the total amount of a drug present in the body at a given moment is 2.0 g and its plasma concentration is 25 μ g/ml, its volume of distribution is

A) 100 L B) 80 L C) 60 L D) 50 L

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Question 222 Medium

The most important factor governing absorption of a drug from intact skin is

A) Molecular weight of the drug B) Site of application C) Lipid solubility of the drug D) Nature of the base used in the formulation

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Question 223 Medium

Bioavailability differences among oral formulations of a drug are most likely to occur if the drug

A) Is freely water soluble B) Is completely absorbed C) Is incompletely absorbed D) Undergoes little first-pass metabolism

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Question 224 Easy

Bioavailability of drug refers to

A) Percentage of administered dose that reaches systemic circulation in the unchanged form B) Ratio of oral to parenteral dose C) Ratio of orally administered drug to that excreted in the faeces D) Ratio of drug excreted unchanged in urine to that excreted as metabolites

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Question 225 Medium

Tricyclic antidepressants can alter the oral absorption of many drugs by

A) Complexing with the other drug in the intestinal lumen B) Altering gut motility C) Altering gut flora D) Damaging gut mucosa

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Question 226 Medium

Active transport of a substance across biological membranes has the following characteristics except

A) It is specific B) It is pH dependent C) It is saturable D) It requires metabolic energy

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Question 227 Medium

The most important factor which governs diffusion of drugs across capillaries other than those in the brain is

A) Blood flow through the capillary B) Lipid solubility of the drug C) pKa value of the drug D) pH of the medium

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Question 228 Easy

Which of the following is a weakly acidic drug

A) Atropine sulfate B) Chloroquine phosphate C) Ephedrine hydrochloride D) Phenytoin sodium

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Question 229 Medium

Which of the following drugs is most likely to be absorbed from the stomach

A) Morphine sulfate B) Diclofenac sodium C) Hyoscine hydrobromide D) Quinine dihydrochloride

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Question 230 Easy

Diffusion of drugs across cell membrane

A) Is dependent upon metabolic activity of the cell B) Is competitively inhibited by chemically related drugs C) Is affected by extent of ionization of drug molecules D) Exhibits saturation kinetics

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