Pharmacology - Comprehensive Mock Test 16

Question 151 Medium

Which adverse drug effect is more common in children than in adults

A) Isoniazid induced neuropathy B) Chlorpromazine induced muscle dystonia C) Digoxin induced cardiac arrhythmia D) Penicillin hypersensitivity

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Question 152 Medium

The pharmacokinetics of drugs in the neonate differs from that in adults, because their

A) Intestinal transit is fast B) Drug metabolizing enzymes are overactive C) Tubular transport mechanisms are not well developed D) Glomerular filtration rate is high

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Question 153 Medium

Interindividual variations in equieffective doses of a drug are most marked if it is disposed by

A) Glomerular filtration B) Tubular secretion C) Both glomerular filtration and tubular secretion D) Hepatic metabolism

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Question 154 Hard

A fixed dose combination preparation meant for internal use must <u>not</u> contain the following class of drug

A) Thiazide diuretic B) Fluoroquinolone antimicrobial C) Corticosteroid D) H2 blocker

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Question 155 Medium

Fixed dose combination formulations are not necessarily appropriate for

A) Drugs administered in standard doses B) Drugs acting by the same mechanism C) Antitubercular drugs D) Antihypertensive drugs

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Question 156 Medium

Which of the following statements is not true of fixed dose combination formulations

A) They are more convenient B) Contraindication to one of the components does not contraindicate the formulation C) The dose of any one component cannot be independently adjusted D) The time course of action of the different components may not be identical

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Question 157 Medium

A drug which is generally administered in standard doses without the need for dose individualization is

A) Insulin B) Mebendazole C) Prednisolone D) Digoxin

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Question 158 Hard

The dose of the following class of drugs has to be adjusted by repeated measurement of the affected physiological parameter

A) Oral contraceptives B) Antiepileptics C) Antidepressants D) Oral anticoagulants

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Question 159 Medium

The following is a competitive antagonist of GABA but a noncompetitive antagonist of diazepam

A) Picrotoxin B) Muscimol C) Flumazenil D) Bicuculline

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Question 160 Medium

The following is not a feature of competitive antagonists

A) Chemical resemblance with the agonist B) Parallel rightward shift of the agonist log doseresponse curve C) Suppression of maximal agonist response D) Apparent reduction in agonist affinity for the receptor

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