Pharmacology - Comprehensive Mock Test 21

Question 201 Medium

If a drug undergoes net tubular secretion, its renal clearance will be

A) More than the glomerular filtration rate B) Equal to the glomerular filtration rate C) Less than the glomerular filtration rate D) Equal to the rate of urine formation

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Question 202 Medium

Glomerular filtration of a drug is affected by its

A) Lipid solubility B) Plasma protein binding C) Degree of ionization D) Rate of tubular secretion

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Question 203 Medium

Drugs which undergo high degree of first-pass metabolism in liver

A) Have low oral bioavailability B) Are excreted primarily in bile C) Are contraindicated in liver disease D) Exhibit zero order kinetics of elimination

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Question 204 Medium

Select the drug that undergoes extensive first-pass metabolism in the liver

A) Phenobarbitone B) Propranolol C) Phenylbutazone D) Theophylline

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Question 205 Medium

The following drug metabolizing reaction is entirely nonmicrosomal

A) Glucuronide conjugation B) Acetylation C) Oxidation D) Reduction

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Question 206 Easy

Microsomal enzyme induction can be a cause of

A) Tolerance B) Physical dependence C) Psychological dependence D) Idiosyncrasy

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Question 207 Medium

The most commonly occurring conjugation reaction for drugs and their metabolites is

A) Glucuronidation B) Acetylation C) Methylation D) Glutathione conjugation

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Question 208 Medium

The following is <u>not</u> true of the cytochrome P450 isoenzyme CYP2D6

A) It generates the hepatotoxic metabolite N-acetyl benzoquinone immine from paracetamol B) It is involved in demethylation of codeine into morphine C) Its altered form is responsible for poor capacity to hydroxylate many drugs including metoprolol D) It is inhibited by quinidine

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Question 209 Hard

Which of the following cytochrome P450 isoenzymes is involved in the metabolism of largest number of drugs in human beings and has been implicated in some dangerous drug interactions

A) CYP 3A4 B) CYP 2C9 C) CYP 2E1 D) CYP 1A2

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Question 210 Easy

A prodrug is

A) The prototype member of a class of drugs B) The oldest member of a class of drugs C) An inactive drug that is transformed in the body to an active metabolite D) A drug that is stored in body tissues and is then gradually released in the circulation

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