Pharmacology - Comprehensive Mock Test 20

Question 191 Medium

Sustained/controlled release oral dosage form is appropriate for the following type of drug

A) An antiarthritic with a plasma half life of 24 hr B) A sleep inducing hypnotic with a plasma half life of 2 hours C) An antihypertensive with a plasma half life of 3 hours D) An analgesic with a plasma half life of 6 hours used for relief of casual headache

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Question 192 Medium

Monitoring plasma drug concentration is useful while using

A) Antihypertensive drugs B) Levodopa C) Lithium carbonate D) MAO inhibitors

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Question 193 Medium

Monitoring of blood levels of diuretic drugs is not practised because

A) No sensitive methods for measuring blood levels of diuretics are available B) It is easier to measure the effect of these drugs C) Response to diuretics is not related to their blood levels D) Diuretics need activation in the body

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Question 194 Hard

When the same dose of a drug is repeated at half life intervals, the steady-state (plateau) plasma drug concentration is reached after

A) 2–3 half lives B) 4–5 half lives C) 6–7 half lives D) 8–10 half lives

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Question 195 Hard

If the clearance of a drug remains constant, doubling the dose rate will increase the steady-state plasma drug concentration by a factor of

A) 3 B) 2 C) 1.5 D) 1.3

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Question 196 Hard

If a drug has a constant bioavailability and first order elimination, its maintenance dose rate will be directly proportional to its

A) Volume of distribution B) Plasma protein binding C) Lipid solubility D) Total body clearance

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Question 197 Easy

If a drug is eliminated by first order kinetics

A) A constant amount of the drug will be eliminated per unit time B) Its clearance value will remain constant C) Its elimination half life will increase with dose D) It will be completely eliminated from the body in 2 × half life period

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Question 198 Medium

Which of the following is <u>not</u> a primary/fundamental, but a derived pharmacokinetic parameter

A) Bioavailability B) Volume of distribution C) Clearance D) Plasma half life

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Question 199 Hard

If a drug is excreted in urine at the rate of 10 mg/hr at a steady-state plasma concentration of 5 mg/L, then its renal clearance is

A) 0.5 L/hr B) 2.0 L/hr C) 5.0 L/hr D) 20 L/hr

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Question 200 Medium

The plasma half life of penicillin-G is longer in the new born because their

A) Plasma protein level is low B) Drug metabolizing enzymes are immature C) Glomerular filtration rate is low D) Tubular transport mechanisms are not well developed

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