Pharmacology - Comprehensive Mock Test 18

Question 171 Easy

‘Drug efficacy’ refers to

A) The range of diseases in which the drug is beneficial B) The maximal intensity of response that can be produced by the drug C) The dose of the drug needed to produce half maximal effect D) The dose of the drug needed to produce therapeutic effect

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Question 172 Medium

Which of the following drugs exhibits ‘therapeutic window’ phenomenon

A) Captopril B) Furosemide C) Diazepam D) Imipramine

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Question 173 Medium

When therapeutic effects decline both below and above a narrow range of doses, a drug is said to exhibit

A) Ceiling effect B) Desensitization C) Therapeutic window phenomenon D) Nonreceptor mediated action

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Question 174 Medium

The following statement is not true of log dose-response curve

A) It is almost linear except at the ends B) It is a rectangular hyperbola C) It facilitates comparison of different agonists D) It can help in discriminating between competitive and noncompetitive antagonists

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Question 175 Medium

Down regulation of receptors can occur as a consequence of

A) Continuous use of agonists B) Continuous use of antagonists C) Chronic use of CNS depressants D) Denervation

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Question 176 Easy

A receptor which itself has enzymatic property is

A) Insulin receptor B) Progesterone receptor C) Thyroxine receptor D) Glucagon receptor

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Question 177 Medium

The receptor transduction mechanism with the fastest time-course of response effectuation is

A) Adenylyl cyclase-cyclic AMP pathway B) Phospholipase C-IP3: DAG pathway C) Intrinsic ion channel operation D) Protein synthesis modulation

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Question 178 Hard

All of the following subserve as intracellular second messengers in receptor mediated signal transduction <u>except</u>

A) Cyclic AMP B) Inositol trisphosphate C) Diacyl glycerols D) G proteins

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Question 179 Medium

Agonist induced autophosphorylation, internalization and down regulation is a distinctive feature of

A) G-protein coupled receptors B) Intrinsic ion channel containing receptors C) Tyrosine protein kinase receptors D) Receptors regulating gene expression

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Question 180 Medium

Select the receptor that is located intracellularly

A) Opioid μ receptor B) Steroid receptor C) Prostaglandin receptor D) Angiotensin receptor

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