Pharmacology - Comprehensive Mock Test 19

Question 181 Medium

Which of the following is a G protein coupled receptor

A) Muscarinic cholinergic receptor B) Nicotinic cholinergic receptor C) Glucocorticoid receptor D) Insulin receptor

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Question 182 Hard

The following receptor type has 7 helical membrane spanning amino acid segments with 3 extracellular and 3 intracellular loops

A) Tyrosine protein kinase receptor B) Gene expression regulating receptor C) Intrinsic ion channel containing receptor D) G protein coupled receptor

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Question 183 Medium

Receptors perform the following function/functions

A) Ligand recognition B) Signal transduction C) Both ligand recognition and signal transduction D) Disposal of agonists and antagonists

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Question 184 Medium

Agonists affect the receptor molecule in the following manner

A) Alter its amino acid sequence B) Denature the receptor protein C) Alter its folding or alignment of subunits D) Induce covalent bond formation

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Question 185 Easy

Receptor agonists possess

A) Affinity but no intrinsic activity B) Intrinsic activity but no affinity C) Affinity and intrinsic activity with a + sign D) Affinity and intrinsic activity with a – sign

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Question 186 Medium

A partial agonist can antagonise the effects of a full agonist because it has

A) High affinity but low intrinsic activity B) Low affinity but high intrinsic activity C) No affinity and low intrinsic activity D) High affinity but no intrinsic activity

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Question 187 Medium

Study of drug-receptor interaction has now shown that

A) Maximal response occurs only when all receptors are occupied by the drug B) Drugs exert an ‘all or none’ action on a receptor C) Receptor and drugs acting on it have rigid complementary ‘lock and key’ structural features D) Properties of ‘affinity’ and ‘intrinsic activity’ are independently variable

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Question 188 Medium

Drugs acting through receptors exhibit the following features except

A) Structural specificity B) High potency C) Competitive antagonism D) Dependence of action on lipophilicity

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Question 189 Easy

What is true in relation to drug receptors

A) All drugs act through specific receptors B) All drug receptors are located on the surface of the target cells C) Agonists induce a conformational change in the receptor D) Partial agonists have low affinity for the receptor

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Question 190 Medium

Which of the following drugs acts by inhibiting an enzyme in the body

A) Atropine B) Allopurinol C) Levodopa D) Metoclopramide

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